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Thanks to its soothing properties, its relaxing effects and its anti-inflammatory action, cannabidiol (CBD) will very quickly become your natural ally to overcome chronic stress, d omnipresent... Voir plus ...

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Cannabidiol (CBD), your natural ally for overcoming stress and anxiety!

Do you suffer from recalcitrant stress or bouts of anxiety that ruin your daily life? You are not the only one!

According to the OpinionWay survey, 9 out of 10 French people say they are stressed, and 61% consider themselves "stressed most of the time". Also, 40% of French people report that their stress level has increased over the past three years, with a direct impact on the quality of their sleep (54%), on their behavior (40%) and their family and/or couple life (26%).

This finding partly explains the massive consumption of CBD products in France, including full-spectrum or broad-spectrum oils, capsules, cannabidiol capsules and CBD flowers.

Buying CBD for stress: how does it work?

But how does CBD work in your body to regulate your mood and neutralize your stress? We explain…

#1 CBD and cannabinoid receptor modulation

Cannabidiol (CBD) is an agonist of the cannabinoid 'CB1' and 'CB2' receptors, which are involved in regulating the body's response to stress and anxiety. By binding to cannabinoid receptors, CBD can modulate their activity and thus regulate your reaction to stressful or anxiety-provoking situations such as public speaking, an important exam, a conflict situation at work, a job interview, etc.

Note: CBD also helps reduce stress and anxiety in people who suffer from social phobia or are anxious by nature.

#2 CBD and the regulation of cortisol synthesis

Cortisol, or hydrocortisone, is a steroid hormone produced by the adrenal gland which contributes to the increase in blood sugar, the inhibition of the immune response, the regulation of the metabolism but also the modulation of the response to stress.

In a recent study, a team of researchers demonstrated that CBD could inhibit the expression of genes coding for the synthesis of this hormone in the neurons of the hypothalamus.

This regulation of cortisol synthesis helps temper your body's response to stress and anxiety.

#3 CBD and increased GABA levels

GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter that plays an important role in regulating anxiety and stress.

GABA works by reducing neuronal excitability by binding to GABA-A receptors, resulting in inhibition of nerve transmission. Empirical observations demonstrate that GABA levels are often abnormally low in people with anxiety disorders and/or chronic stress.

Studies in the mid-2010s showed that insufficient levels of GABA can lead to increased neuronal excitability and anxiety. These studies also explain that:

  • Drugs that increase GABA levels, such as benzodiazepines, can reduce anxiety and stress;
  • Supplements containing GABA may reduce anxiety in people with anxiety disorders, but these findings have not been confirmed by studies in larger populations.

According to clinical observations, CBD seems to increase GABA levels, especially in certain brain regions involved in mood regulation such as the amygdala. This increase in GABA levels helps reduce anxiety responses by increasing neural inhibition.

#4 CBD and the regulation of emotional responses

Regions of the brain involved in regulating your mood are typically rich in CB 1 and CB 2 endocannabinoid receptors.

This is the case, for example, of the striatum, a brain structure that plays a major role in motivation, movement, emotional responses and mood.

Cannabidiol and other cannabinoids from the hemp plant (CBG and CBN in particular) therefore act indirectly on the activity of the striatum to promote emotional balance and bring you a moment of serenity.

#5 CBD and inhibition of the pro-inflammatory response

Finally, CBD is widely acclaimed for its anti-inflammatory and analgesic effects (against pain).

By inhibiting the pro-inflammatory response, CBD thus reduces the response to stress and anxiety which manifests itself in inflammatory episodes, including intense itching and stomach aches.

CBD, stress and sleep quality

The soothing and relaxing action of cannabidiol (CBD) allows organisms tested by stress and anxiety to regain a balance of life and to evolve more serenely, but that's not all.

By bringing you this parenthesis of calm and peace, CBD also acts on your circadian rhythm and improves the quality of your sleep.

Lack of sleep: a public health problem in France

Like stress, lack of sleep seems widespread in France.

According to the sleep barometer of Public Health France, the French have lost almost an hour and a half of sleep per night in about fifty years. Thus, our nights would be only 6 hours and 32 minutes long... much less than the 7 to 8 hours recommended by sleep specialists.

The consequences are serious: mood disorders, chronic fatigue, headaches, risk of developing heart disease or type 2 diabetes, etc.

These studies that show the benefits of CBD on sleep

A study carried out on 103 adult patients who suffered from sleep problems related to episodes of stress and anxiety demonstrated the beneficial effects of CBD on sleep quality. About 80% of patients who were supplemented with CBD saw their stress and anxiety scores drop substantially, and 66.7% of them saw a marked improvement in their sleep score. "All signals converge on a calming effect of cannabidiol (CBD) on the central nervous system", can we read in particular in the study report view here.

In another study, cannabidiol (CBD) consumed in oil form provided relief from REM sleep disorders in adult patients, with action against:

  • Insomnia
  • Unwanted awakenings;
  • Nocturnal verbalization (talking in sleep);
  • Twitching and jerking during sleep;
  • Disorders related to excessive daytime sleepiness (or hypersomnia).

Our online store provides you with premium quality CBD products to neutralize your stress and improve the quality of your sleep.

CBD oil: a practical and effective format against stress!

Along with the CBD flower, cannabidiol oil is one of the formats preferred by French consumers. It must be said that this CBD product combines the advantages:

  • This is a 'liquid' CBD product delivered ready for consumption;
  • The best cannabidiol oils are packaged in compact bottles that can slip discreetly into a bag or pocket;
  • Bottles of CBD oil usually include a dropper to make it easier to take and to control the dosage.

There are three types of CBD oils:

  1. Full spectrum CBD oil (full spectrum). These are hemp oils that contain all the cannabinoids (CBG, CBN, CBC), terpenes and other natural compounds found in Cannabis L. Sativa and Cannabis Indica (with the exception of THC, limited to less than 0.2%, in accordance with the regulations in force in France).
  2. Broad Spectrum CBD Oil. These are hemp oils that contain the majority of the components of legal cannabis, but generally have fewer terpenes and fewer cannabinoids of the CBN, CBG and CBC type. A full spectrum CBD oil that has lost some of its cannabinoids or terpenes during the transformation process will, for example, be requalified as broad spectrum CBD oil.
  3. "CBD isolate" type oil. As the name suggests, it is a pure oil that contains 100% cannabidiol, without any other components of the hemp plant.

Features of CBD Oil

Full Spectrum CBD Oil

Broad Spectrum CBD Oil

CBD Isolate






< 0.2% (vigilance)



Other cannabinoids (CBG, CBC, CBN, CBNA)












Smell and taste




Available format for this product

Oil, alcoholature

Oil, alcoholature

CBD crystals or powder

Comparative table of CBD oils Full Spectrum (full spectrum), Broad Spectrum (broad spectrum) and CBD Isolate

How to use CBD oil to relieve your stress?

If you suffer from stress and anxiety issues, we advise you to opt for a full spectrum type of CBD oil for one simple reason: the "entourage effect". This concept describes the synergy of the different cannabinoids (CBD, CBG, CBN and CBC), terpenes and flavonoids of the hemp plant, whose action is increased tenfold when they are ingested collectively. The "relaxation" effect is then more marked, and the analgesic and anti-inflammatory effects are more powerful. Some usage tips:

  • If you are a beginner, start with a low dosage CBD oil, with a rate between 5 and 10%. You can increase the dose gradually depending on your body's reaction to CBD and other cannabinoids;
  • To get results, you need to be regular and consume your CBD oil daily. The approach of restricting your consumption of CBD (oil, infusion, capsules, flower capsules) only to times when you feel stress or anxiety does not allow you to feel the beneficial effects of cannabidiol;
  • Choose a quality, reliable CBD oil full of good cannabinoids. Our online store offers you CBD oils tested by independent laboratories, a guarantee of quality but also of compliance with the regulations in force in France, in particular with regard to the THC level;
  • Opt for sublingual consumption, placing a few drops of CBD oil under the tongue. Wait a minute, then swallow the remaining oil if necessary. This mode of consumption guarantees optimal and above all rapid effects, just a few minutes after taking CBD;
  • Be patient, as the effects of CBD, regardless of the product chosen, may take several days or even weeks for some people. Persevere and stay consistent.

The CBD oil dosage (in number of drops) depends on your weight and the CBD level of your oil. To help you, here is a concrete example with a 10% concentrated CBD oil.


Quantity (in mg of product)

Quantity (in number of product drops)


20mg per day

4 drops


25mg per day

5 drops


30mg per day

6 drops

70 kg

35mg per day

7 drops

80 kg

40mg per day

8 drops


45mg per day

9 drops

100 kg

50mg per day

10 drops

Tips for Consuming Full Spectrum CBD Oil for Stress and Anxiety Relief

Is CBD legal in France?

CBD products can be freely marketed in France, provided that their THC level is below 0.2%. In the eyes of the legislator, this almost zero rate guarantees the absence of any psychotropic effect. Our online store offers you CBD products that are 100% compliant with current legislation at a smart price and free delivery anywhere in France, with no minimum purchase.

321CBD, the benchmark for anti-stress CBD in France!

Discover the calming and soothing power of CBD with 321CBD, the reference online store for anti-stress cannabidiol in France.

Our products are carefully selected and tested to ensure a premium experience. Whether you're looking to combat stress and anxiety or improve the quality of your sleep, we've got you covered.

From CBD oil to fruity gummies, from concentrated resin to flowers of legendary strains, our wide range of products will meet all your needs.

Order now and get fast, free shipping, with no minimum purchase!

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