But then, is it possible to combine CBD with taking medication for a particular condition? Scientific studies agree that it is quite possible to take medication while consuming CBD, although there are some precautions to take that we will describe in the content of this page. Generally speaking, CBD is a very safe product, with very few if any side effects.
In this article, we're going to guide you on the things you need to know before taking CBD, as well as the interactions between drugs and CBD in metabolism. In addition, below you will also find many scientific studies on the subject and tips on how to make your experience with CBD as beneficial as possible.
Cannabidiol (CBD), a trusted product
Indeed, many scientific studies agree that cannabidiol (CBD) is safe for the human body. The molecule in question does not make you "stoned" and has no effect on the various pathologies that an individual may have. Moreover, CBD is not addictive as other components of hemp could be This scientific study confirms it. CBD is a natural plant extract from a plant widely used for its therapeutic benefits. It can be considered as a natural remedy
What does the World Health Organization (WHO) say about cannabidiol? It states that CBD is not harmful to health and is not classified as a controlled substance (as dangerous drugs might be). Furthermore, according to the WHO, CBD has no effects that indicate abuse or addiction potential.
The only way CBD could be dangerous is if it is overdosed. According to the American laboratories, CBD overdose is defined from a consumption of more than 20,000 mg per day, an amount very difficult to reach for a lambda consumer.
How does CBD interact with drugs?
Generally speaking, CBD does not interact dangerously with drugs. Unlike alcohol, there is no rule that says CBD and medication do not mix
On the contrary, many patients with major medical conditions find themselves consuming CBD in addition to their medication because CBD provides a more natural, less restrictive and above all, effective quite quickly, especially in terms of pain and anxiety.
What happens in the body when we ingest CBD?
Once ingested, CBD, just like drugs, is metabolized by the liver before being distributed in the body. The liver will use special enzymes to break down the CBD into smaller components (metabolites) and distribute them throughout the body via the bloodstream. This process could not be more natural.
When ingesting CBD and drugs at the same time, a phenomenon is created: the liver focuses all its attention on the CBD components and leaves the other drugs, which should also be broken down into smaller components and distributed in the body. It is notably the cytochrome P450 enzyme that is at the origin of this phenomenon
But is this phenomenon dangerous? It can be restrictive in the sense that some drugs must be broken down and distributed quickly after ingestion because if they stagnate too much, they can create side effects (nausea, headache ...) very annoying for the patient.
In short, the intake of drugs metabolized by the cytochrone P450 enzyme in the liver at the same time as CBD will be affected by this phenomenon. Some steroids, antibiotics, antidepressants, beta-blockers and antihistamines fall into this category. According to a US study in 2020a list of 57 drugs that can be affected by CBD has been established.
Among these 57 drugs whose action could be disrupted by CBD, we find antidepressants (amitriptyline, clomipramine and lofepramine), oral contraceptives (ethinylestradiol), analgesics (fentanyl), thyroid drugs (levothyroxine), sedatives (propofol) and anti-coagulants (acenocoumarol and warfarin).
Note that the dosage of CBD as well as the drug in question, age, weight, health condition of the consumer in addition to other factors are crucial information that can make this interaction vary in positive or negative.
Interesting fact: A component of grapefruit also interacts like CBD with drugs in the liver.
Are all forms of CBD equal?
No, not all forms face this metabolism phenomenon equally. As you probably already know, different types of consumption allow for different types of effects. Inhaled CBD works fastest through the bloodstream, with the most CBD consumed
On the other hand, CBD used as an ointment or edible will have very little effect because less CBD in it and will take longer to act
For CBD to interact with drugs as explained above, it needs to reach a high peak in its dosage, which is not the case in all consumptions.
Indications for consuming CBD along with medication
After understanding how it all works, the question remains unanswered. Should you use CBD while taking medication?
As you understood from the article, drugs and CBD do not produce a destructive potion when combined, as drugs with alcohol might. Rather, it's more a matter of the liver getting confused which could cause discomfort when ingesting both at the same time.
Moreover, it is important to keep in mind that the studies take into account consumption levels ranging from 200 to 400mg per day, which is the regular consumption of very few people in the end.
To take precautions and prevent this potential problem, here are some tips to consider when taking CBD and drugs at the same time:
First, space out your medication intake with CBD by a few hours. This gives the liver time to do its job properly with each ingestion.
Second, always tell your doctor. It is he who will tell you what dose of CBD will suit your intake
Finally, always use quality products, give preference to quality productsIn particular, products approved by the French government, which are very strict on the protocol of production and distribution of CBD products in France